NDLI: Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma

Content Provider	PubMed Central
Author	Chen, Eleanor Y. Deran, Michael T. Ignatius, Myron S. Grandinetti, Kathryn Brooke Clagg, Ryan Mccarthy, Karin M. Lobbardi, Riadh M. Brockmann, Jillian Keller, Charles Wu, Xu Langenau, David M.
Abstract	Embryonal rhabdomyosarcoma (ERMS) is a cancer of skeletal muscle and is one of the most common pediatric cancers of soft tissue. There is no effective treatment for patients with relapsed ERMS, with less than 50% surviving the disease. The self-renewing and molecularly defined tumor propagating cells (TPCs) drive continued tumor growth and relapse. Yet to date, drugs targeting ERMS self-renewal and differentiation of TPCs have not been identified. Our study describes a large-scale chemical screen to identify targetable pathways essential for modulating self-renewal and differentiation of ERMS and demonstrates the feasibility of inducing differentiation of TPCs in ERMS by small molecules.
Related Links	http://dx.doi.org/10.1073/pnas.1317731111
Ending Page	5354
Page Count	6
Starting Page	5349
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	111
Language	English
Publisher	National Academy of Sciences
Publisher Date	2014-04-08
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma