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| Content Provider | PubMed Central |
|---|---|
| Author | Sisman, Ali Rıza Muge, Kiray Mehmet, Camsari Ulas Evren, Merve Ates, Mehmet Baykara, Basak Aksu, Ilkay Guven, Di Uysal, Nazan |
| Copyright Year | 2014 |
| Abstract | Background. It is well known that diabetes mellitus may cause testicular damage. Vascular endothelial growth factor (VEGF) and nerve growth factor beta (NGF- β ) are important neurotrophic factors for male reproductive system. Objective. We aimed to investigate the correlation between testicular damage and testicular VEGF and NGF- β levels in diabetic rats. Methods. Diabetes was induced by streptozotocin (STZ, 45 mg/kg/i.p.) in adult rats. Five weeks later testicular tissue was removed; testicular VEGF and NGF- β levels were measured by ELISA. Testicular damage was detected by using hematoxylin and eosin staining and periodic acid-Schiff staining, and apoptosis was identified by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL). Seminiferous tubular sperm formation was evaluated using Johnsen's score. Results. In diabetic rats, seminiferous tubule diameter was found to be decreased; basement membrane was found to be thickened in seminiferous tubules and degenerated germ cells. Additionally, TUNEL-positive cells were increased in number of VEGF+ cells and levels of VEGF and NGF- β were decreased in diabetic testes. Correlation between VEGF and NGF- β levels was strong. Conclusion. These results suggest that the decrease of VEGF and NGF- β levels is associated with the increase of the apoptosis and testicular damage in diabetic rats. Testis VEGF and NGF- β levels could be potential novel biomarkers for diabetes induced testicular damage. |
| Related Links | http://dx.doi.org/10.1155/2014/108106 |
| Starting Page | 108106 |
| File Format | |
| ISSN | 02780240 |
| e-ISSN | 18758630 |
| Journal | Disease Markers |
| Volume Number | 2014 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Clinical Biochemistry Genetics Molecular Biology Biochemistry, medical Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Genetics Clinical Biochemistry Molecular Biology |
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