Loading...
Please wait, while we are loading the content...
Similar Documents
The Mechanisms Underlying α-Amanitin Resistance in Drosophila melanogaster: A Microarray Analysis
| Content Provider | PubMed Central |
|---|---|
| Author | Mitchell, Chelsea L. Saul, Michael C. Lei, Liang Wei, Hairong Werner, Thomas |
| Editor | Claude, Wicker-thomas |
| Copyright Year | 2014 |
| Abstract | The rapid evolution of toxin resistance in animals has important consequences for the ecology of species and our economy. Pesticide resistance in insects has been a subject of intensive study; however, very little is known about how Drosophila species became resistant to natural toxins with ecological relevance, such as α-amanitin that is produced in deadly poisonous mushrooms. Here we performed a microarray study to elucidate the genes, chromosomal loci, molecular functions, biological processes, and cellular components that contribute to the α-amanitin resistance phenotype in Drosophila melanogaster. We suggest that toxin entry blockage through the cuticle, phase I and II detoxification, sequestration in lipid particles, and proteolytic cleavage of α-amanitin contribute in concert to this quantitative trait. We speculate that the resistance to mushroom toxins in D. melanogaster and perhaps in mycophagous Drosophila species has evolved as cross-resistance to pesticides, other xenobiotic substances, or environmental stress factors. |
| Related Links | http://dx.doi.org/10.1371/journal.pone.0093489 |
| Starting Page | 93489 |
| File Format | |
| ISSN | 19326203 |
| e-ISSN | 19326203 |
| Journal | PLoS ONE |
| Issue Number | 4 |
| Volume Number | 9 |
| Language | English |
| Publisher | Public Library of Science |
| Access Restriction | Open |
| Rights Holder | Public Library of Science |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
