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| Content Provider | PubMed Central |
|---|---|
| Author | Peelle, Jonathan E. Powers, John Cook, Philip A. Smith, Edward E. Grossman, Murray |
| Abstract | We hypothesize that semantic memory for object concepts involves both representations of visual feature knowledge in modality-specific association cortex and heteromodal regions that are important for integrating and organizing this semantic knowledge so it can be used in a flexible, contextually appropriate manner. We examined this hypothesis in an fMRI study of mild Alzheimer’s disease (AD). Participants were presented with pairs of printed words and asked whether the words match on a given visual-perceptual feature (e.g. guitar, violin: SHAPE). Stimuli probed natural kinds and manufactured objects, and judgments involved shape or color. We found activation of bilateral ventral temporal cortex and left dorsolateral prefrontal cortex during semantic judgments, with AD patients showing less activation of these regions than healthy seniors. Moreover, AD patients showed less ventral temporal activation relative to healthy seniors for manufactured objects but not natural kinds. We also used diffusion-weighted MRI of white matter to examine fractional anisotropy (FA). Patients with AD showed significantly reduced FA in the superior longitudinal fasciculus and inferior frontal-occipital fasciculus that carry projections linking temporal and frontal regions of this semantic network. Our results are consistent with the hypothesis that semantic memory is supported in part by a large-scale neural network involving modality-specific association cortex, heteromodal association cortex and projections between these regions. The semantic deficit in AD thus arises from gray matter disease that affects the representation of feature knowledge and processing its content, as well as white matter disease that interrupts the integrated functioning of this large-scale network. |
| Related Links | http://dx.doi.org/10.3758/s13415-013-0239-6 |
| Ending Page | 48 |
| Page Count | 12 |
| Starting Page | 37 |
| File Format | |
| ISSN | 15307026 |
| e-ISSN | 1531135X |
| Journal | Cognitive, affective & behavioral neuroscience |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher Date | 2014-03-01 |
| Access Restriction | Open |
| Subject Keyword | Cognitive Neuroscience Behavioral Neuroscience Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cognitive Neuroscience Behavioral Neuroscience |
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