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| Content Provider | PubMed Central |
|---|---|
| Author | Drumm, Bernard T. Sergeant, Gerard P. Hollywood, Mark A. Thornbury, Keith T. Matsuda, Toshio T. Baba, Akemichi Harvey, Brian J. Mchale, Noel G. |
| Copyright Year | 2014 |
| Abstract | Interstitial cells of Cajal (ICC) act as putative pacemaker cells in the rabbit urethra. Pacemaker activity in ICC results from spontaneous global Ca2+ waves that can be increased in frequency by raising external [K+]. The purpose of this study was to elucidate the mechanism of this response. Intracellular [Ca2+] was measured in fluo‐4‐loaded smooth muscle cells (SMCs) and ICC using a Nipkow spinning disk confocal microscope. Increasing [K+]o to 60 mmol/L caused an increase in [Ca2+]i accompanied by contraction in SMCs. Raising [K+]o did not cause contraction in ICC, but the frequency of firing of spontaneous calcium waves increased. Reducing [Ca2+]o to 0 mmol/L abolished the response in both cell types. Nifedipine of 1 μmol/L blocked the response of SMC to high [K+]o, but did not affect the increase in firing in ICC. This latter effect was blocked by 30 μmol/L NiCl2 but not by the T‐type Ca2+ channel blocker mibefradil (300 nmol/L). However, inhibition of Ca2+ influx via reverse‐mode sodium/calcium exchange (NCX) using either 1 μmol/L SEA0400 or 5 μmol/L KB‐R7943 did block the effect of high [K+]o on ICC. These data suggest that high K+ solution increases the frequency of calcium waves in ICC by increasing Ca2+ influx through reverse‐mode NCX. |
| Related Links | http://dx.doi.org/10.1002/phy2.203 |
| Starting Page | 203 |
| File Format | |
| ISSN | 2051817X |
| e-ISSN | 2051817X |
| Journal | Physiological Reports |
| Issue Number | 1 |
| Volume Number | 2 |
| Language | English |
| Publisher | Wiley Periodicals, Inc. |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Rights Holder | Wiley Periodicals, Inc. |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) |
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