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| Content Provider | PubMed Central |
|---|---|
| Author | Yamada, Norie Shigefuku, Ryuta Sugiyama, Ryuichi Kobayashi, Minoru Ikeda, Hiroki Takahashi, Hideaki Chiaki, Okuse Suzuki, Michihiro Itoh, Fumio Hiroshi, Yotsuyanagi Yasuda, Kiyomi Moriya, Kyoji Koike, Kazuhiko Wakita, Takaji Kato, Takanobu |
| Copyright Year | 2014 |
| Abstract | A 47-year-old man presented with general fatigue and dark urine. The laboratory data showed increased levels of hepatic transaminases. The patient was positive for hepatitis B virus (HBV) markers and negative for anti-human immunodeficiency virus. The HBV-DNA titer was set to 7.7 log copies/mL. The patient was diagnosed with acute hepatitis B. The HBV infection route was obscure. The serum levels of hepatic transaminases decreased to normal ranges without any treatment, but the HBV-DNA status was maintained for at least 26 mo, indicating the presence of persistent infection. We isolated HBV from the acute-phase serum and determined the genome sequence. A phylogenetic analysis revealed that the isolated HBV was genotype H. In this patient, the elevated peak level of HBV-DNA and the risk alleles at human genome single nucleotide polymorphisms s3077 and rs9277535 in the human leukocyte antigen-DP locus were considered to be risk factors for chronic infection. This case suggests that there is a risk of persistent infection by HBV genotype H following acute hepatitis; further cases of HBV genotype H infection must be identified and characterized. Thus, the complete determination of the HBV genotype may be essential during routine clinical care of acute hepatitis B outpatients. |
| Related Links | http://dx.doi.org/10.3748/wjg.v20.i11.3044 |
| Starting Page | 3044 |
| File Format | |
| ISSN | 10079327 |
| Journal | World Journal of Gastroenterology : WJG |
| Issue Number | 11 |
| Volume Number | 20 |
| Language | English |
| Publisher | Baishideng Publishing Group Co., Limited |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Rights Holder | Baishideng Publishing Group Co., Limited |
| Subject Keyword | Gastroenterology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
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