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| Content Provider | PubMed Central |
|---|---|
| Author | Omoto, Itaru Matsumoto, Masataka Okumura, Hiroshi Uchikado, Yasuto Setoyama, Tetsuro Kita, Yoshiaki Owaki, Tetsuhiro Kijima, Yuko Hiroyuki, Shinchi Ishigami, Sumiya Ueno, Shinichi Shoji, Natsugoe |
| Copyright Year | 2014 |
| Abstract | Lymph node metastasis is one of the most important prognostic factors in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor (VEGF)-C and its receptor, VEGF receptor-3 (VEGFR-3), are key in the process of lymphangiogenesis. The present study immunohistochemically examined the expression of VEGF-C, VEGFR-3 and D2-40 in 119 patients with ESCC, and microlymphatic vessel density (MLVD) was calculated based on D2-40 expression counts. Positive expression of VEGF-C was found to correlate significantly with depth of tumor invasion, lymphatic invasion and lymph node metastasis (P<0.001, P<0.0001 and P<0.0001, respectively). Patients with deeper tumor invasion showed higher positivity of VEGFR-3 expression (P<0.05), while patients with lymph node metastasis showed higher MLVD (P<0.05). When patients were divided into three groups according to the expression of VEGF-C and VEGFR-3, patients with coexpression of VEGF-C and VEGFR-3 exhibited poorer prognosis and higher MLVD. The VEGF-C/VEGFR-3 axis is important in tumor lymphangiogenesis. |
| Related Links | http://dx.doi.org/10.3892/ol.2014.1823 |
| Starting Page | 1027 |
| File Format | |
| ISSN | 17921074 |
| e-ISSN | 17921082 |
| Journal | Oncology Letters |
| Issue Number | 4 |
| Volume Number | 7 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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