NDLI: Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection

Content Provider	PubMed Central
Author	Lee, Suki M. Y. Kok, Kin-hang Jaume, Martial Cheung, Timothy K. W. Yip, Tsz-fung Lai, Jimmy C. C. Guan, Yi Webster, Robert G. Jin, Dong-yan Peiris, J. S. Malik
Abstract	Toll-like receptors (TLRs) play key roles in innate immune recognition of pathogens leading to the activation of innate host defenses and sometimes to immunopathology. In humans, there are 10 identified TLR members, designated TLRs 1–10. Of those, TLR10 remains the only one without a defined ligand or function. We now provide previously unidentified evidence that TLR10 plays a role in innate immune responses following influenza viral infection. Influenza viruses are subtyped on the hemagglutinin (H) and neuraminidase (N) proteins. Compared with seasonal influenza virus H1N1, the highly pathogenic avian influenza virus H5N1 is a more potent inducer of TLR10 expression. Given the importance of innate immune sensing receptors in host defense and pathogenesis, evidence of a functional role for TLR10 in influenza infection suggests that this receptor probably plays a role in a range of other viral and perhaps other microbial diseases.
Related Links	http://dx.doi.org/10.1073/pnas.1324266111
Ending Page	3798
Page Count	6
Starting Page	3793
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	111
Language	English
Publisher	National Academy of Sciences
Publisher Date	2014-03-11
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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