NDLI: Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

Please wait, while we are loading the content...

Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.

Isolation of high affinity human antibodies directly from large synthetic repertoires.

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature.

Mutations in the alpha 2(IV) basement membrane collagen gene of Caenorhabditis elegans produce phenotypes of differing severities.

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus.

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.

Quality and position of the three lac operators of E. coli define efficiency of repression.

A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction.

Roles of RNase E, RNase II and PNPase in the degradation of the rpsO transcripts of Escherichia coli: stabilizing function of RNase II and evidence for efficient degradation in an ams pnp rnb mutant.

An S18 ribosomal protein gene copy at the Arabidopsis PFL locus affects plant development by its specific expression in meristems.

A functional site of the GTPase-associated center within 28S ribosomal RNA probed with an anti-RNA autoantibody.

Replicator dominance in a eukaryotic chromosome.

Tn 10 transposition in vivo: temporal separation of cleavages at the two transposon ends and roles of terminal basepairs subsequent to interaction of ends.

Year: 1994, Volume: 13, Issue: 13

Year: 1994, Volume: 13, Issue: 12

Year: 1994, Volume: 13, Issue: 11

Year: 1994, Volume: 13, Issue: 10

Year: 1994, Volume: 13, Issue: 9

Year: 1994, Volume: 13, Issue: 8

Year: 1994, Volume: 13, Issue: 7

Year: 1994, Volume: 13, Issue: 6

Year: 1994, Volume: 13, Issue: 5

Year: 1994, Volume: 13, Issue: 4

Year: 1994, Volume: 13, Issue: 3

Year: 1994, Volume: 13, Issue: 2

Year: 1994, Volume: 13, Issue: 1

Year: 1993, Volume: 12

Year: 1992, Volume: 11

Year: 1991, Volume: 10

Year: 1990, Volume: 9

Year: 1989, Volume: 8

Year: 1988, Volume: 7

Year: 1987, Volume: 6

Year: 1986, Volume: 5

Year: 1985, Volume: 4

Year: 1984, Volume: 3

Year: 1983, Volume: 2

Year: 1982, Volume: 1

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

Content Provider	PubMed Central
Author	Koch, K. W. Lambrecht, H. G. Haberecht, M. Redburn, D. Schmidt, H. H.
Abstract	Electrophysiological recordings on retinal rod cells, horizontal cells and on-bipolar cells indicate that exogenous nitric oxide (NO) has neuromodulatory effects in the vertebrate retina. We report here endogenous NO formation in mammalian photoreceptor cells. Photoreceptor NO synthase resembled the neuronal NOS type I from mammalian brain. NOS activity utilized the substrate L-arginine (Km = 4 microM) and the cofactors NADPH, FAD, FMN and tetrahydrobiopterin. The activity showed a complete dependence on the free calcium concentration ([Ca2+]) and was mediated by calmodulin. NO synthase activity was sufficient to activate an endogenous soluble guanylyl cyclase that copurified in photoreceptor preparations. This functional coupling was strictly controlled by the free [Ca2+] (EC50 = 0.84 microM). Activation of the soluble guanylyl cyclase by endogenous NO was up to 100% of the maximal activation of this enzyme observed with the exogenous NO donor compound sodium nitroprusside. This NO/cGMP pathway was predominantly localized in inner and not in outer segments of photoreceptors. Immunocytochemically, we localized NO synthase type I mainly in the ellipsoid region of the inner segments and a soluble guanylyl cyclase in cell bodies of cone photoreceptor cells. We conclude that in photoreceptors endogenous NO is functionally coupled to a soluble guanylyl cyclase and suggest that it has a neuromodulatory role in visual transduction and in synaptic transmission in the outer retina.
Starting Page	3312
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	14
Volume Number	13
Language	English
Publisher Date	1994-07-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Role of Nitric Oxide, Nitric Oxide Synthase, Soluble Guanylyl Cyclase, and cGMP-Dependent Protein Kinase I in Mouse Stem Cell Cardiac Development

Functional Significance of Cytosolic Endothelial Nitric-oxide Synthase (eNOS) REGULATION OF HYPERPERMEABILITY

Dynamic Ligand Exchange in Soluble Guanylyl Cyclase (sGC) IMPLICATIONS FOR sGC REGULATION AND DESENSITIZATION

The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase

Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries

Dark-dependent soluble guanylyl cyclase activity in locust photoreceptor cells

Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo

Hydroxyurea induces fetal hemoglobin by the nitric oxide–dependent activation of soluble guanylyl cyclase

Structural basis for endothelial nitric oxide synthase binding to calmodulin

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

Similar Documents

Role of Nitric Oxide, Nitric Oxide Synthase, Soluble Guanylyl Cyclase, and cGMP-Dependent Protein Kinase I in Mouse Stem Cell Cardiac Development

Functional Significance of Cytosolic Endothelial Nitric-oxide Synthase (eNOS) REGULATION OF HYPERPERMEABILITY

Dynamic Ligand Exchange in Soluble Guanylyl Cyclase (sGC) IMPLICATIONS FOR sGC REGULATION AND DESENSITIZATION

The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase

Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries

Dark-dependent soluble guanylyl cyclase activity in locust photoreceptor cells

Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo

Hydroxyurea induces fetal hemoglobin by the nitric oxide–dependent activation of soluble guanylyl cyclase

Structural basis for endothelial nitric oxide synthase binding to calmodulin

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.