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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Xiaona Zhao, Haiyuan Shao, Yilan Wang, Pei Wei, Yanru Zhang, Weiqian Jiang, Jing Chen, Yan Zhang, Zhigang |
| Copyright Year | 2014 |
| Abstract | Inorganic arsenic (iAs) is a toxic metalloid found ubiquitously in the environment. In humans, exposure to iAs can result in toxicity and cause toxicological manifestations. Arsenic trioxide (As2O3) has been used in the treatment for acute promyelocytic leukemia. The kidney is the critical target organ of trivalent inorganic As (iAsIII) toxicity. We examine if oral administration of astaxanthin (AST) has protective effects on nephrotoxicity and oxidative stress induced by As2O3 exposure (via intraperitoneal injection) in rats. Markers of renal function, histopathological changes, Na+-K+ ATPase, sulfydryl, oxidative stress, and As accumulation in kidneys were evaluated as indicators of As2O3 exposure. AST showed a significant protective effect against As2O3-induced nephrotoxicity. These results suggest that the mechanisms of action, by which AST reduces nephrotoxicity, may include antioxidant protection against oxidative injury and reduction of As accumulation. These findings might be of therapeutic benefit in humans or animals suffering from exposure to iAsIII from natural sources or cancer therapy. |
| Related Links | http://dx.doi.org/10.4162/nrp.2014.8.1.46 |
| Ending Page | 53 |
| Page Count | 8 |
| Starting Page | 46 |
| File Format | |
| ISSN | 20056168 |
| e-ISSN | 20056168 |
| Journal | Nutrition Research and Practice |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | The Korean Nutrition Society and the Korean Society of Community Nutrition |
| Publisher Date | 2014-02-01 |
| Access Restriction | Open |
| Rights Holder | The Korean Nutrition Society and the Korean Society of Community Nutrition |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Food Science |
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