NDLI: Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA Lys gene

Content Provider	PubMed Central
Author	Shimizu, Akinori Mito, Takayuki Hayashi, Chisato Ogasawara, Emi Koba, Ryusuke Negishi, Issei Takenaga, Keizo Nakada, Kazuto Hayashi, Jun-ichi
Abstract	We generated transmitochondrial mito-mice-tRNALys7731 as models for precise examination of the pathogenesis and transmission profiles of mtDNA mutations in the tRNA Lys genes and have obtained important information regarding primary prevention of the diseases caused by the mtDNA mutations. Although nuclear transplantation from oocytes of affected mothers into enucleated oocytes of unrelated women has been suggested, the methodology carries the technical risk of inducing nuclear abnormalities and prompts ethical concerns regarding the production of three-parent babies with normal mtDNA from unrelated oocyte donors. The current study suggests that the selection of oocytes with high proportions of normal mtDNA from affected mothers can be used to avoid these issues and therefore provides insights into mitochondrial genetics and medicine.
Related Links	http://dx.doi.org/10.1073/pnas.1318109111
Ending Page	3109
Page Count	6
Starting Page	3104
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	111
Language	English
Publisher	National Academy of Sciences
Publisher Date	2014-02-25
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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