NDLI: Stability of mRNA influences osteoporotic bone mass via CNOT3

Content Provider	PubMed Central
Author	Watanabe, Chiho Morita, Masahiro Hayata, Tadayoshi Nakamoto, Tetsuya Chisato, Kikuguchi Li, Xue Kobayashi, Yasuhiro Takahashi, Naoyuki Takuya, Notomi Moriyama, Keiji Yamamoto, Tadashi Yoichi, Ezura Noda, Masaki
Abstract	Osteoporosis is a highly prevalent disease affecting nearly 20 million people in the United States and is life-threatening in elderly patients. However, underlying pathophysiology regarding the posttranscriptional control of bone resorption is incompletely understood. CNOT3 is a molecule involved in mRNA stability in yeast to mammalian cells, but its role in bone regulation is not known. We discovered that Cnot3 deficiency specifically enhances receptor activator of NF-κB (RANK) mRNA stability and leads to osteopenia in healthy young adult animals. Moreover, Cnot3 levels are reduced in ageing-induced osteoporosis, and Cnot3 deficiency further exacerbates such osteoporosis significantly. As a mechanism, Cnot3 binds to RANK mRNA and its 3′-UTR renders Cnot3-dependent instability to the reporter gene. Our results reveal Cnot3 regulation in aging-induced osteoporosis.
Related Links	http://dx.doi.org/10.1073/pnas.1316932111
Ending Page	2697
Page Count	6
Starting Page	2692
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	111
Language	English
Publisher	National Academy of Sciences
Publisher Date	2014-02-18
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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