NDLI: Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire

Content Provider	PubMed Central
Author	Rowland, Sarah L. Tuttle, Kathryn Torres, Raul M. Pelanda, Roberta
Copyright Year	2012
Abstract	Immature B cells are generated daily in the bone marrow tissue. More than half of the newly generated immature B cells are autoreactive and bind a self-antigen, while the others are nonautoreactive. A selection process has evolved on the one hand to thwart development of autoreactive immature B cells and, on the other hand, to promote further differentiation of nonautoreactive immature B cells into transitional and mature B cells. These negative and positive selection events are carefully regulated by signals that emanate from the antigen receptor, whether antigen-mediated or tonic, and are influenced by signals that are generated by receptors that bind cytokines, chemokines, and other factors produced in the bone marrow tissue. These signals, therefore, are the predominant driving forces for the generation of a B cell population that is capable of protecting the body from infections while maintaining self-tolerance. Here, we review recent findings from our group and others that describe how tonic antigen receptor signaling and bone marrow cytokines regulate the selection of immature B cells.
Related Links	http://dx.doi.org/10.1007/s12026-012-8366-7
Ending Page	240
Page Count	10
Starting Page	231
File Format	PDF
ISSN	0257277X
e-ISSN	15590755
Journal	Immunologic research
Issue Number	0
Volume Number	55
Language	English
Publisher Date	2013-03-01
Access Restriction	Open
Subject Keyword	Immunology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology

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