NDLI: Lipid signals and insulin resistance

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Lipid signals and insulin resistance

Content Provider	PubMed Central
Author	Zhang, Chongben Klett, Eric L. Coleman, Rosalind A.
Copyright Year	2013
Abstract	The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intolerance, dyslipidemia and hypertension, is a major risk factor for cardiovascular disease. Insulin resistance has been proposed to be the common feature that links obesity to the metabolic syndrome, but the mechanism remains obscure. Although the excess content of triacylglycerol in muscle and liver is highly associated with insulin resistance in these tissues, triacylglycerol itself is not causal but merely a marker. Thus, attention has turned to the accumulation of cellular lipids known to have signaling roles. This review will discuss recent progress in understanding how glycerolipids and related lipid intermediates may impair insulin signaling.
Related Links	http://dx.doi.org/10.2217/clp.13.67
Ending Page	667
Page Count	9
Starting Page	659
File Format	PDF
ISSN	17584302
e-ISSN	17584302
Journal	Clinical lipidology
Issue Number	6
Volume Number	8
Language	English
Publisher Date	2013-12-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine

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