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Role of Branching of Hydrophilic Domain on Physicochemical Properties of Amphiphilic Macromolecules
| Content Provider | PubMed Central |
|---|---|
| Author | Abdelhamid, Dalia Arslan, Hulya Zhang, Yingyue Uhrich, Kathryn E. |
| Abstract | A novel series of amphiphilic macromolecules (AMs) composed of a sugar backbone, aliphatic chains, and branched, hydrophilic poly(oligoethylene glycol) methyl ether methacrylate (POEGMA)were developed for drug delivery applications. The branched, hydrophilic domains (POEGMA homopolymers with one hydroxyl group) were prepared via atom transfer radical polymerization (ATRP) of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) monomers using 2-hydroxyethyl-2-bromoisobutyrate (HEBiB) as an initiator and copper bromide/bipyridine (CuBr/Bpy) as the catalyst system. To form the amphiphilic structures, the branched POEGMAs were coupled to hydrophobic domains that were formed via acylation of a sugar backbone. The impact of branching in the hydrophilic domain was investigated by comparing the AMs’ solution and thermal properties with those of the linear counterparts. Although these highly branched AMs showed similar critical micelle concentration (CMC) values as compared to linear analogues, they possessed quite low glass transition (Tg ) temperatures. Consequently, these novel AMs with branched hydrophilic domain combine the desirable thermal properties of POEGMA with favorable solution properties of amphiphilic architectures, which make them suitable for injectable drug delivery systems. |
| Related Links | http://dx.doi.org/10.1039/c3py01072d |
| Ending Page | 1462 |
| Page Count | 6 |
| Starting Page | 1457 |
| File Format | |
| ISSN | 17599954 |
| e-ISSN | 17599962 |
| Journal | Polymer chemistry |
| Issue Number | 4 |
| Volume Number | 5 |
| Language | English |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Organic Chemistry Biochemistry Bioengineering Polymers and Plastics Biomedical Engineering Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics |
