NDLI: Osteoclastogenesis accompanying early osteoblastic differentiation of BMSCs promoted by mechanical stretch

Content Provider	PubMed Central
Author	Wu, Yuqiong Zhang, Peng Dai, Qinggang Fu, Runqing Yang, Xiao Fang, Bing Jiang, Lingyong
Copyright Year	2013
Abstract	Mechanical stress plays a crucial role in bone formation and absorption. In previous studies, we verified the osteoblastogenesis of bone mesenchymal stem cells (BMSCs) affected by intermittent traction stretch. However, little is known about the osteoclastogenesis process under mechanical stimulation and its underlying association with osteoblastogenesis. In the present study, we investigated the osteoclastogenesis of BMSCs under this special mechanical stress. BMSCs were subjected to 10% elongation for 1–7 days using a Flexcell Strain Unit and then the mRNA levels of osteoclastic genes were examined. The results indicated time-dependent varying of mRNA levels of the receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in BMSCs at different stretching time points. The ratio of RANKL/OPG increased at the early stage of mechanical stimulation (5 days) and decreased to a low level at a later stage (7 days). Findings of this study may help to understand the correlations between osteoblastogenesis and osteoclasteogenesis when mechanical stretch induces the osteoblastic differentiation of BMSCs.
Related Links	http://dx.doi.org/10.3892/br.2013.84
Ending Page	478
Page Count	5
Starting Page	474
File Format	PDF
ISSN	20499434
e-ISSN	20499442
Journal	Biomedical Reports
Issue Number	3
Volume Number	1
Language	English
Publisher	D.A. Spandidos
Publisher Date	2013-03-01
Access Restriction	Open
Rights Holder	D.A. Spandidos
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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