NDLI: Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

Content Provider	PubMed Central
Author	Andersen, Anne Poder Moreira, José M. A. Pedersen, Stine Falsig
Copyright Year	2014
Abstract	Major changes in intra- and extracellular pH homoeostasis are shared features of most solid tumours. These changes stem in large part from the metabolic shift of most cancer cells towards glycolytic metabolism and other processes associated with net acid production. In combination with oncogenic signalling and impact from factors in the tumour microenvironment, this upregulates acid-extruding plasma membrane transport proteins which maintain intracellular pH normal or even more alkaline compared with that of normal cells, while in turn acidifying the external microenvironment. Mounting evidence strongly indicates that this contributes significantly to cancer development by favouring e.g. cancer cell migration, invasion and chemotherapy resistance. Finally, while still under-explored, it seems likely that non-cancer cells in the tumour microenvironment also exhibit altered pH regulation and that this may contribute to their malignant properties. Thus, the physical tumour microenvironment and the cancer and stromal cells within it undergo important reciprocal interactions which modulate the tumour pH profile, in turn severely impacting on the course of cancer progression. Here, we summarize recent knowledge of tumour metabolism and the tumour microenvironment, placing it in the context of tumour pH regulation, and discuss how interfering with these properties may be exploited clinically.
Related Links	http://dx.doi.org/10.1098/rstb.2013.0098
Starting Page	20130098
File Format	PDF
ISSN	14712970
e-ISSN	14712970
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Issue Number	1638
Volume Number	369
Language	English
Publisher	The Royal Society
Publisher Date	2014-03-19
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interaction of tumour cells with their microenvironment: ion channels and cell adhesion molecules. A focus on pancreatic cancer

Ion channels and transporters in tumour cell migration and invasion

Functional properties of ion channels and transporters in tumour vascularization

Ion channels and transporters in the development of drug resistance in cancer cells

Ion channels and transporters in the development of drug resistance in cancer cells

Ion channels/transporters as epigenetic regulators? —a microRNA perspective

Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk.

Ion channels and apoptosis in cancer

Ion channels and anti-cancer immunity

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

Similar Documents

Interaction of tumour cells with their microenvironment: ion channels and cell adhesion molecules. A focus on pancreatic cancer

Ion channels and transporters in tumour cell migration and invasion

Functional properties of ion channels and transporters in tumour vascularization

Ion channels and transporters in the development of drug resistance in cancer cells

Ion channels and transporters in the development of drug resistance in cancer cells

Ion channels/transporters as epigenetic regulators? —a microRNA perspective

Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk.

Ion channels and apoptosis in cancer

Ion channels and anti-cancer immunity

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment