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Tumor Suppressive microRNAs in Lung Cancer: Diagnostic and Therapeutic Opportunities
| Content Provider | PubMed Central |
|---|---|
| Author | Sempere, Lorenzo F. Liu, Xi Dmitrovsky, Ethan |
| Abstract | Lung cancer is the leading cause of cancer-related death for both men and women in the United States. As for many other cancer types, lung cancer is not a single disease, but rather a variety of diseases that present different histopathological, molecular and clinical characteristics. Improved diagnostic and therapeutic tools are needed to manage and treat lung cancer patients. microRNAs are a recently-discovered class of short non-coding RNAs, which constitutes a novel and functionally-important layer of gene regulation. Using new mouse transgenic models for lung cancer, Liu and colleagues reported a genome-wide microRNA expression analysis and identified a signature of downregulated microRNAs in lung cancer tissues relative to adjacent normal lung. This signature was validated in clinical specimens from lung cancer patients, underscoring the relevance of this profile to human lung cancer. In vitro experiments demonstrated that restoring miR-34c, miR-145 or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines. Here, we discuss the clinical implications of these findings for lung cancer biology, therapy and prevention. |
| Related Links | http://dx.doi.org/10.1100/tsw.2009.88 |
| Ending Page | 628 |
| Page Count | 3 |
| Starting Page | 626 |
| File Format | |
| ISSN | 1537744X |
| e-ISSN | 1537744X |
| Journal | TheScientificWorldJournal |
| Volume Number | 9 |
| Language | English |
| Publisher Date | 2009-01-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Environmental Science(all) Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology Environmental Science |
