NDLI: Electrochemical Sensors for Detection of Acetylsalicylic Acid

Content Provider	PubMed Central
Author	Supalkova, Veronika Petrek, Jiri Havel, Ladislav Sona, Krizkova Petrlova, Jitka Adam, Vojtech David, Potesil Babula, Petr Beklova, Miroslava Horna, Ales Rene, Kizek
Copyright Year	2006
Abstract	Acetylsalicylic acid (AcSA), or aspirin, was introduced in the late 1890s and has been used to treat a variety of inflammatory conditions. The aim of this work was to suggest electrochemical sensor for acetylsalicylic detection. Primarily, we utilized square wave voltammetry (SWV) using both carbon paste electrode (CPE) and of graphite pencil electrode (GPE) as working ones to indirect determination of AcSA. The principle of indirect determination of AcSA bases in its hydrolysis on salicylic acid (SA), which is consequently detected. Thus, we optimized both determination of SA and conditions for AcSA hydrolysis and found out that the most suitable frequency, amplitude, step potential and the composition and pH of the supporting electrolyte for the determination of SA was 260 Hz, 50 mV, 10 mV and Britton-Robinson buffer (pH 1.81), respectively. The detection limit (S/N = 3) of the SA was 1.3 ng/ml. After that, we aimed on indirect determination of AcSA by SWV CPE. We tested the influence of pH of Britton-Robinson buffer and temperature on yield of hydrolysis, and found out that 100% hydrolysis of AcSA was reached after 80 minutes at pH 1.81 and 90°C. The method for indirect determination of AcSA has been utilized to analyse pharmaceutical drug. The determined amount of AcSA in the pharmaceutical drug was in good agreement with the declared amounts. Moreover, we used GPE for determination of AcSA in a pharmaceutical drug. Base of the results obtained from stationary electrochemical instrument we used flow injection analysis with electrochemical detection to determine of salicylates (SA, AcSA, thiosalicylic acid, 3,5-dinitrosalicylic acid and 5-sulfosalicylic acid – SuSA). We found out that we are able to determine all of detected salicylates directly without any pre-treatment, hydrolysis and so on at units of femtomoles per injection (5 μl).
Ending Page	1497
Starting Page	1483
File Format	PDF
ISSN	14248220
e-ISSN	14248220
Journal	Sensors (Basel, Switzerland)
Issue Number	11
Volume Number	6
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2006-11-01
Access Restriction	Open
Rights Holder	Molecular Diversity Preservation International (MDPI)
Subject Keyword	Sensors and actuators Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Atomic and Molecular Physics, and Optics Instrumentation Analytical Chemistry Biochemistry Information Systems Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Electrochemical DNA Sensors for Detection of DNA Damage

Electrochemical Sensors for Clinic Analysis

Electrochemical Detection of Hydrazine Using Poly(dopamine)-Modified Electrodes

A Study on Tannic Acid-doped Polypyrrole Films on Gold Electrodes for Selective Electrochemical Detection of Dopamine

Carbon Nanomaterials Based Electrochemical Sensors/Biosensors for the Sensitive Detection of Pharmaceutical and Biological Compounds

Disposable Screen Printed Electrochemical Sensors: Tools for Environmental Monitoring

Electrochemical Sensors Based on Organic Conjugated Polymers

Centrifugal Microfluidic System for Nucleic Acid Amplification and Detection

Computational Modeling of the Electrochemical System of Lipase Activity Detection

Electrochemical Sensors for Detection of Acetylsalicylic Acid

Similar Documents

Electrochemical DNA Sensors for Detection of DNA Damage

Electrochemical Sensors for Clinic Analysis

Electrochemical Detection of Hydrazine Using Poly(dopamine)-Modified Electrodes

A Study on Tannic Acid-doped Polypyrrole Films on Gold Electrodes for Selective Electrochemical Detection of Dopamine

Carbon Nanomaterials Based Electrochemical Sensors/Biosensors for the Sensitive Detection of Pharmaceutical and Biological Compounds

Disposable Screen Printed Electrochemical Sensors: Tools for Environmental Monitoring

Electrochemical Sensors Based on Organic Conjugated Polymers

Centrifugal Microfluidic System for Nucleic Acid Amplification and Detection

Computational Modeling of the Electrochemical System of Lipase Activity Detection

Electrochemical Sensors for Detection of Acetylsalicylic Acid