NDLI: Hype or hypervirulence

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Hype or hypervirulence

Content Provider	PubMed Central
Author	Smits, Wiep Klaas
Copyright Year	2013
Abstract	Clostridium difficile infections (CDI) have emerged as a major cause of healthcare associated disease, and recent epidemiological evidence also suggests an important role in community-acquired diarrhea. This increase is associated with specific types, especially PCR ribotypes 027 and 078, which are sometimes referred to as “hypervirulent”. Over the past years major advances have been made in our understanding of C. difficile pathogenicity, with the identification and characterization of the major clostridial toxins TcdA and TcdB. However, the relation between the toxins, their regulation, and “hypervirulence” remain unclear. Here I review our current understanding of C. difficile pathogenicity and argue that “hypervirulent” is an inadequate term to describe PCR ribotypes 027 and 078, that the ability of C. difficile to cause problematic infections is a consequence of a multifactorial process that extends beyond toxins, sporulation, and antimicrobial resistance, and that vigilance is in order toward types that are closely related to ribotypes 027 and 078, but are currently not considered problematic.
Related Links	http://dx.doi.org/10.4161/viru.26297
Ending Page	596
Page Count	5
Starting Page	592
File Format	PDF
ISSN	21505594
e-ISSN	21505608
Journal	Virulence
Issue Number	7
Volume Number	4
Language	English
Publisher	Landes Bioscience
Publisher Date	2013-10-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Immunology Microbiology (medical) Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology Microbiology (medical)

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