NDLI: The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons

Content Provider	PubMed Central
Author	Manuel, Marin Daniel, Zytnicki Meunier, Claude
Copyright Year	2014
Abstract	Spinal motoneurons may display a variety of firing patterns including bistability between repetitive firing and quiescence and, more rarely, bistability between two firing states of different frequencies. It was suggested in the past that firing bistability required that the persistent L-type calcium current be segregated in distal dendrites, far away from the spike generating currents. However, this is not supported by more recent data. Using a two compartment model of motoneuron, we show that the different firing patterns may also result from the competition between the more proximal dendritic component of the dendritic L-type conductance and the calcium sensitive potassium conductance responsible for afterhypolarization (AHP). Further emphasizing this point, firing bistability may be also achieved when the L-type current is put in the somatic compartment. However, this requires that the calcium-sensitive potassium conductance be triggered solely by the high threshold calcium currents activated during spikes and not by calcium influx through the L-type current. This prediction was validated by dynamic clamp experiments in vivo in lumbar motoneurons of deeply anesthetized cats in which an artificial L-type current was added at the soma. Altogether, our results suggest that the dynamical interaction between the L-type and afterhyperpolarization currents is as fundamental as the segregation of the calcium L-type current in dendrites for controlling the discharge of motoneurons.
Related Links	http://dx.doi.org/10.3389/fncom.2014.00004
Starting Page	4
File Format	PDF
ISSN	16625188
e-ISSN	16625188
Journal	Frontiers in Computational Neuroscience
Volume Number	8
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Cellular and Molecular Neuroscience Neuroscience (miscellaneous) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cellular and Molecular Neuroscience

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