NDLI: A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control

Please wait, while we are loading the content...

A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control

Content Provider	PubMed Central
Author	Kim, Ernest S. Erich, Gustenhoven Mescher, Mark J. Leary, Pararas Erin E. Smith, Kim A. Spencer, Abigail J. Tandon, Vishal Borenstein, Jeffrey T. Fiering, Jason
Abstract	Reciprocating microfluidic drug delivery, as compared to steady or pulsed infusion, has unique features which may be advantageous in many therapeutic applications. We have previously described a device, designed for wearable use in small animal models, which periodically infuses then withdraws a sub-microliter volume of drug solution to and from the endogenous fluid of the inner ear. This delivery approach results in zero net volume of liquid transfer while enabling mass transport of compounds to the cochlea by means of diffusion and mixing. We report here on an advanced wearable delivery system aimed at further miniaturization and complex dose protocols. Enhancements to the system include the incorporation of a planar micropump to generate reciprocating flow and a novel drug reservoir which maintains zero net volume delivery and permits programmable modulation of the drug concentration in the infused bolus. The reciprocating pump is fabricated from laminated polymer films and employs a miniature electromagnetic actuator to meet the size and weight requirements of a head-mounted in vivo guinea pig testing system. The reservoir comprises a long microchannel in series with a micropump, connected in parallel with the reciprocating flow network. We characterized in vitro the response and repeatability of the planar pump and compared the results with a lumped element simulation. We also characterized the performance of the reservoir, including repeatability of dosing and range of dose modulation. Acute in vivo experiments were performed in which the reciprocating pump was used to deliver a test compound to the cochlea of anesthetized guinea pigs to evaluate short-term safety and efficacy of the system. These advances are key steps toward realization of an implantable device for long-term therapeutic applications in humans.
Related Links	http://dx.doi.org/10.1039/c3lc51105g
Ending Page	721
Page Count	12
Starting Page	710
File Format	PDF
ISSN	14730197
e-ISSN	14730189
Journal	Lab on a chip
Issue Number	4
Volume Number	14
Language	English
Publisher Date	2014-01-01
Access Restriction	Open
Subject Keyword	Biochemistry Bioengineering Chemistry(all) Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Microfluidic Electroporation for Cellular Analysis and Delivery

Preprogrammed capillarity to passively control system-level sequential and parallel microfluidic flows

Microfluidic waves

Microfluidic oscillators with widely tunable periods

A Microfluidic D-subminiature Connector

Microfluidic Droplet Sorting with a High Frequency Ultrasound Beam

Nanostructured microfluidic digestion system for rapid high-performance proteolysis

Probing cell-cell communication with microfluidic devices

Microfluidic Remote Loading for Rapid Single-Step Liposomal Drug Preparation

A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control

Similar Documents

Microfluidic Electroporation for Cellular Analysis and Delivery

Preprogrammed capillarity to passively control system-level sequential and parallel microfluidic flows

Microfluidic waves

Microfluidic oscillators with widely tunable periods

A Microfluidic D-subminiature Connector

Microfluidic Droplet Sorting with a High Frequency Ultrasound Beam

Nanostructured microfluidic digestion system for rapid high-performance proteolysis

Probing cell-cell communication with microfluidic devices

Microfluidic Remote Loading for Rapid Single-Step Liposomal Drug Preparation

A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control