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  1. Molecules (Basel, Switzerland)
  2. Year: 2013, Volume: 18
  3. Year: 2013, Volume: 18, Issue: 4
  4. Protostane and Fusidane Triterpenes: A Mini-Review
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Year: 2015, Volume: 20
Year: 2014, Volume: 20
Year: 2014, Volume: 19
Year: 2013, Volume: 18
Year: 2013, Volume: 18, Issue: 12
Year: 2013, Volume: 18, Issue: 11
Year: 2013, Volume: 18, Issue: 10
Year: 2013, Volume: 18, Issue: 9
Year: 2013, Volume: 18, Issue: 8
Year: 2013, Volume: 18, Issue: 7
Year: 2013, Volume: 18, Issue: 6
Year: 2013, Volume: 18, Issue: 5
Year: 2013, Volume: 18, Issue: 4
Protostane and Fusidane Triterpenes: A Mini-Review
Application Scope and Limitations of TADDOL-Derived Chiral Ammonium Salt Phase-Transfer Catalysts
Year: 2013, Volume: 18, Issue: 3
Year: 2013, Volume: 18, Issue: 2
Year: 2012, Volume: 17
Year: 2011, Volume: 16
Year: 2010, Volume: 15
Year: 2009, Volume: 14
Year: 2008, Volume: 13
Year: 2007, Volume: 12
Year: 2006, Volume: 11

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Protostane and Fusidane Triterpenes: A Mini-Review

Content Provider PubMed Central
Author Zhao, Ming Goedecke, Tanja Gunn, Jordan Duan, Jin-ao Che, Chun-tao
Copyright Year 2013
Abstract Protostane triterpenes belong to a group of tetracyclic triterpene that exhibit unique structural characteristics. Their natural distribution is primarily limited to the genus Alisma of the Alismataceae family, but they have also been occasionally found in other plant genera such as Lobelia, Garcinia, and Leucas. To date, there are 59 known structures of protostane. Many of them have been reported to possess biological properties such as improving lipotropism, hepato-protection, anti-viral activity against hepatitis B and HIV-I virus, anti-cancer activity, as well as reversal of multidrug resistance in cancer cells. On the other hand, fusidanes are fungal products characterized by the 29-nor protostane structures. They possess antibiotic properties against staphylococci, including the methicillin-resistant staphylococcus aureus (MRSA). Fusidic acid is a representative member which has found clinical applications. This review covers plant sources of the protostanes, their structure elucidation, characteristic structural and spectral properties, as well as biological activities. The fungal sources, structural features, structure-activity relationship and biological activities of fusidanes are also covered in this review. Additionally, the biogenesis of these two types of triterpene is discussed and a refined pathway is proposed.
Related Links http://dx.doi.org/10.3390/molecules18044054
Ending Page 4080
Page Count 27
Starting Page 4054
File Format PDF
ISSN 14203049
e-ISSN 14203049
Journal Molecules (Basel, Switzerland)
Issue Number 4
Volume Number 18
Language English
Publisher Date 2013-04-01
Access Restriction Open
Subject Keyword Organic Chemistry Research in Higher Education
Content Type Text
Resource Type Article
Subject Organic Chemistry Medicine Drug Discovery Analytical Chemistry Physical and Theoretical Chemistry Molecular Medicine Pharmaceutical Science
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