NDLI: Temperature-Sensitive Mutations in Drosophila melanogaster, VII. A Mutation (parats ) Causing Reversible Adult Paralysis

Content Provider	PubMed Central
Author	Suzuki, David T. Thomas, Grigliatti Williamson, Rodney
Abstract	A temperature-sensitive mutation, parats , in Drosophila melanogaster causes an immediate, but reversible, paralysis of adult flies when they are shifted from 22°C to 29°C. The mutation is a sex-linked recessive that maps 2.8 units to the left of f. Wild-type flies observed for 2-hr periods exhibited normal mobility at all temperatures between 22°C and 35°C. From 22°C to 25°C, parats flies were wild type in walking, climbing, and flying ability. At 1-degree intervals above 25°C, parats flies became increasingly debilitated; at 29°C, complete paralysis occurred. After flies were maintained for prolonged intervals at 29°C, some activity could be recovered at that temperature. Studies of the behavior of mosaics at 29°C revealed a requirement of the (+) allele in the head for mobility, and a thoracic component for proper leg movement. Normal electroretinograms were obtained at both 22°C and 30°C. The results suggest a temperature-sensitive defect in the nervous system.
Starting Page	890
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	68
Language	English
Publisher Date	1971-05-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Temperature-Sensitive Mutations in Drosophila melanogaster, VII. A Mutation (parats ) Causing Reversible Adult Paralysis