NDLI: Chromatin Loop Formation in the β-Globin Locus and Its Role in Globin Gene Transcription

Content Provider	PubMed Central
Author	Kim, Aeri Dean, Ann
Copyright Year	2012
Abstract	Although linearly distant along mouse chromosome 7 and human chromosome 11, the mammalian β-globin gene is located in close proximity to the upstream locus control region enhancer when it is actively transcribed in the nuclear chromatin environment of erythroid cells. This organization is thought to generate a chromatin loop between the LCR, a powerful enhancer, and active globin genes by extruding intervening regions containing inactive genes. Loop formation in the β-globin locus requires erythroid specific transcriptional activators, co-factors and insulator-related factors. Chromatin structural features such as histone modifications and DNase I hypersensitive site formation as well as nuclear localization are all involved in loop formation in the locus through diverse mechanisms. Current models envision the formation of the loop as a necessary step in globin gene transcription activation, but this has not been definitively established and many questions remain about what is necessary to achieve globin gene transcription activation.
Related Links	http://dx.doi.org/10.1007/s10059-012-0048-8
Ending Page	5
Page Count	5
Starting Page	1
File Format	PDF
ISSN	10168478
e-ISSN	02191032
Journal	Molecules and Cells
Issue Number	1
Volume Number	34
Language	English
Publisher	Korea Society for Molecular and Cellular Biology
Publisher Date	2012-07-01
Access Restriction	Open
Rights Holder	Korea Society for Molecular and Cellular Biology
Subject Keyword	Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Molecular Biology

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