NDLI: Working memory performance and neural activity in prefrontal cortex of peripubertal monkeys

Content Provider	PubMed Central
Author	Zhou, Xin Zhu, Dantong Qi, Xue-lian Lees, Cynthia J. Bennett, Allyson J. Salinas, Emilio Stanford, Terrence R. Constantinidis, Christos
Copyright Year	2013
Abstract	The dorsolateral prefrontal cortex matures late into adolescence or early adulthood. This pattern of maturation mirrors working memory abilities, which continue to improve into adulthood. However, the nature of the changes that prefrontal neuronal activity undergoes during this process is poorly understood. We investigated behavioral performance and neural activity in working memory tasks around the time of puberty, a developmental event associated with the release of sex hormones and significant neurological change. The developmental stages of male rhesus monkeys were evaluated with a series of morphometric, hormonal, and radiographic measures. Peripubertal monkeys were trained to perform an oculomotor delayed response task and a variation of this task involving a distractor stimulus. We found that the peripubertal monkeys tended to abort a relatively large fraction of trials, and these were associated with low levels of task-related neuronal activity. However, for completed trials, accuracy in the delayed saccade task was high and the appearance of a distractor stimulus did not impact performance significantly. In correct trials delay period activity was robust and was not eliminated by the presentation of a distracting stimulus, whereas in trials that resulted in errors the sustained cue-related activity was significantly weaker. Our results show that in peripubertal monkeys the prefrontal cortex is capable of generating robust persistent activity in the delay periods of working memory tasks, although in general it may be more prone to stochastic failure than in adults.
Related Links	http://dx.doi.org/10.1152/jn.00370.2013
Ending Page	2660
Page Count	13
Starting Page	2648
File Format	PDF
ISSN	15221598
e-ISSN	15221598
Journal	Journal of Neurophysiology
Issue Number	11
Volume Number	110
Language	English
Publisher	American Physiological Society
Publisher Date	2013-12-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology

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