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The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans
| Content Provider | PubMed Central |
|---|---|
| Author | Zhao, Hong French, Jarrod B. Fang, Ye Benkovic, Stephen J. |
| Abstract | Purine nucleotides are ubiquitous molecules that play vital roles in all kingdoms of life, not only as components of nucleic acids, but also participating in signaling and energy storage. Cellular pools of purines are maintained by the tight control of several complementary and sometimes competing processes including de novo biosynthesis, salvage and catabolism of nucleotides. While great strides have been made over the past sixty years in understanding the biosynthesis of purines, we are experiencing a renaissance in this field. In this feature article we discuss the most recent discoveries relating to purine biosynthesis, with particular emphasis upon the dynamic multi-protein complex called the purinosome. In particular we highlight advances made towards understanding the assembly, control and function of this protein complex and the attempts made to exploit this knowledge for drug discovery. |
| Related Links | http://dx.doi.org/10.1039/c3cc41437j |
| File Format | |
| ISSN | 13597345 |
| e-ISSN | 1364548X |
| Journal | Chemical communications (Cambridge, England) |
| Issue Number | 40 |
| Volume Number | 49 |
| Language | English |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Materials Chemistry Electronic, Optical and Magnetic Materials Chemistry(all) Surfaces, Coatings and Films Metals and Alloys Ceramics and Composites Catalysis Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis |
