NDLI: Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions

Content Provider	PubMed Central
Author	Hutchins, Andrew Paul Diez, Diego Diego, Miranda-saavedra
Copyright Year	2013
Abstract	STAT3 is the quintessential pleiotropic transcription factor with many biological roles throughout development as well as in multiple adult tissues. Its functional heterogeneity is encoded in the range of genome-wide binding patterns that specify different regulatory networks in distinct cell types. However, STAT3 does not display remarkable DNA binding preferences that may help correlate specific motifs with individual biological functions or cell types. Therefore, achieving a detailed understanding of the regulatory mechanisms that endow STAT3 (or any other pleiotropic transcription factor) with such a rainbow of functions is not only a central problem in biology but also a fiendishly difficult one. Here we describe key genomic and computational approaches that have shed light into this question, and present the two current models of STAT3 binding (universal and cell type-specific). We also discuss the role that the local epigenetic environment plays in the selection of STAT3 binding sites.
Related Links	http://dx.doi.org/10.4161/jkst.25097
Starting Page	25097
File Format	PDF
ISSN	21623996
e-ISSN	21623996
Journal	JAK-STAT
Issue Number	4
Volume Number	2
Language	English
Publisher	Landes Bioscience
Publisher Date	2013-10-16
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions