NDLI: Regulated aggregative multicellularity in a close unicellular relative of metazoa

Content Provider	PubMed Central
Author	Arnau, Sebé-pedrós Irimia, Manuel Campo, Javier Del Helena, Parra-acero Russ, Carsten Nusbaum, Chad Blencowe, Benjamin J. Ruiz-trillo, Iñaki
Editor	Tautz, Diethard
Copyright Year	2013
Abstract	The evolution of metazoans from their unicellular ancestors was one of the most important events in the history of life. However, the cellular and genetic changes that ultimately led to the evolution of multicellularity are not known. In this study, we describe an aggregative multicellular stage in the protist Capsaspora owczarzaki, a close unicellular relative of metazoans. Remarkably, transition to the aggregative stage is associated with significant upregulation of orthologs of genes known to establish multicellularity and tissue architecture in metazoans. We further observe transitions in regulated alternative splicing during the C. owczarzaki life cycle, including the deployment of an exon network associated with signaling, a feature of splicing regulation so far only observed in metazoans. Our results reveal the existence of a highly regulated aggregative stage in C. owczarzaki and further suggest that features of aggregative behavior in an ancestral protist may had been co-opted to develop some multicellular properties currently seen in metazoans.
Related Links	http://dx.doi.org/10.7554/elife.01287
Starting Page	1287
File Format	PDF
ISSN	2050084X
e-ISSN	2050084X
Journal	eLife
Volume Number	2
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2013-12-01
Access Restriction	Open
Rights Holder	eLife Sciences Publications, Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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