NDLI: Direct Cardiac Reprogramming: From Developmental Biology to Cardiac Regeneration

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Direct Cardiac Reprogramming: From Developmental Biology to Cardiac Regeneration

Content Provider	PubMed Central
Author	Qian, Li Srivastava, Deepak
Abstract	Heart disease affects millions worldwide and is a progressive condition involving loss of cardiomyocytes. The human heart has limited endogenous regenerative capacity and is thus an important target for novel regenerative medicine approaches. While cell-based regenerative therapies hold promise, cellular reprogramming of endogenous cardiac fibroblasts, which represent more than half of the cells in the mammalian heart, may be an attractive alternative strategy for regenerating cardiac muscle. Recent advances leveraging years of developmental biology point to the feasibility of generating de novo cardiomyocyte-like cells from terminally differentiated non-myocytes in the heart in situ after ischemic damage. Here, we review the progress in cardiac reprogramming methods and consider the opportunities and challenges that lie ahead in refining this technology for regenerative medicine.
Related Links	http://dx.doi.org/10.1161/circresaha.112.300625
File Format	PDF
ISSN	00097330
e-ISSN	15244571
Journal	Circulation research
Issue Number	7
Volume Number	113
Language	English
Publisher Date	2013-09-13
Access Restriction	Open
Subject Keyword	Physiology Cardiology and Cardiovascular Medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Cardiology and Cardiovascular Medicine

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