NDLI: Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling

Content Provider	PubMed Central
Author	Björn, Granseth Fukushima, Yuichi Sugo, Noriuki Lagnado, Leon Yamamoto, Nobuhiko
Copyright Year	2013
Abstract	During development, axons form branches in response to extracellular molecules. Little is known about the underlying molecular mechanisms. Here, we investigate how neurotrophin-induced axon branching is related to synaptic vesicle cycling for thalamocortical axons. The exogenous application of brain-derived neurotrophic factor (BDNF) markedly increased axon branching in thalamocortical co-cultures, while removal of endogenous BDNF reduced branching. Over-expression of a C-terminal fragment of AP180 that inhibits clathrin-mediated endocytosis affected the laminar distribution and the number of branch points. A dominant-negative synaptotagmin mutant that selectively targets synaptic vesicle cycling, strongly suppressed axon branching. Moreover, axons expressing the mutant synaptotagmin were resistant to the branch-promoting effect of BDNF. These results suggest that synaptic vesicle cycling might regulate BDNF induced branching during the development of the axonal arbor.
Related Links	http://dx.doi.org/10.3389/fncir.2013.00202
Starting Page	202
File Format	PDF
ISSN	16625110
e-ISSN	16625110
Journal	Frontiers in Neural Circuits
Volume Number	7
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2013-01-01
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Sensory Systems Cognitive Neuroscience Cellular and Molecular Neuroscience Neuroscience (miscellaneous) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Sensory Systems Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Live Imaging of Synaptic Vesicle Release and Retrieval in Dopaminergic Neurons

Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway

Frequency transformation in the auditory lemniscal thalamocortical system

Frequency-Dependent Gating of Synaptic Transmission and Plasticity by Dopamine

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network

Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons

Thalamocortical input onto layer 5 pyramidal neurons measured using quantitative large-scale array tomography

Precise Synaptic Efficacy Alignment Suggests Potentiation Dominated Learning

The impact of short term synaptic depression and stochastic vesicle dynamics on neuronal variability

Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling

Similar Documents

Live Imaging of Synaptic Vesicle Release and Retrieval in Dopaminergic Neurons

Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway

Frequency transformation in the auditory lemniscal thalamocortical system

Frequency-Dependent Gating of Synaptic Transmission and Plasticity by Dopamine

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network

Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons

Thalamocortical input onto layer 5 pyramidal neurons measured using quantitative large-scale array tomography

Precise Synaptic Efficacy Alignment Suggests Potentiation Dominated Learning

The impact of short term synaptic depression and stochastic vesicle dynamics on neuronal variability

Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling