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| Content Provider | PubMed Central |
|---|---|
| Author | Lantier, Louis Sonia, Lacroix-lamandé Laurent, Potiron Coralie, Metton Drouet, Françoise Guesdon, William Audrey, Gnahoui-david Le Vern, Yves Edith, Deriaud Fenis, Aurore Rabot, Sylvie Descamps, Amandine Werts, Catherine Laurent, Fabrice |
| Editor | Dominique, Soldati-favre |
| Copyright Year | 2013 |
| Abstract | Cryptosporidium parvum is a zoonotic protozoan parasite found worldwide, that develops only in the gastrointestinal epithelium and causes profuse diarrhea. Using a mouse model of C. parvum infection, we demonstrated by conditional depletion of CD11c+ cells that these cells are essential for the control of the infection both in neonates and adults. Neonates are highly susceptible to C. parvum but the infection is self-limited, whereas adults are resistant unless immunocompromised. We investigated the contribution of DC to the age-dependent susceptibility to infection. We found that neonates presented a marked deficit in intestinal CD103+ DC during the first weeks of life, before weaning, due to weak production of chemokines by neonatal intestinal epithelial cells (IEC). Increasing the number of intestinal CD103+ DC in neonates by administering FLT3-L significantly reduced susceptibility to the infection. During infections in neonates, the clearance of the parasite was preceded by a rapid recruitment of CD103+ DC mediated by CXCR3-binding chemokines produced by IEC in response to IFNγ. In addition to this key role in CD103+ DC recruitment, IFNγ is known to inhibit intracellular parasite development. We demonstrated that during neonatal infection CD103+ DC produce IL-12 and IFNγ in the lamina propria and the draining lymph nodes. Thus, CD103+DC are key players in the innate immune control of C. parvum infection in the intestinal epithelium. The relative paucity of CD103+ DC in the neonatal intestine contributes to the high susceptibility to intestinal infection. |
| Related Links | http://dx.doi.org/10.1371/journal.ppat.1003801 |
| Starting Page | 1003801 |
| File Format | |
| ISSN | 15537374 |
| e-ISSN | 15537374 |
| Journal | PLoS Pathogens |
| Issue Number | 12 |
| Volume Number | 9 |
| Language | English |
| Publisher | Public Library of Science |
| Publisher Date | 2013-12-01 |
| Access Restriction | Open |
| Rights Holder | Public Library of Science |
| Subject Keyword | Immunology Genetics Molecular Biology Microbiology Parasitology Virology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Virology Molecular Biology Parasitology Immunology Microbiology |
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