NDLI: Anti-inflammatory Effect of Perilla frutescens (L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages

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Year: 2012, Volume: 17, Issue: 1

Anti-inflammatory Effect of Perilla frutescens (L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages

Content Provider	PubMed Central
Author	Lee, Hyun-ah Han, Ji-sook
Copyright Year	2012
Abstract	This study was designed to investigate the inhibitory effects of Perilla frutescens (L.) Britton var. frutescens extract on the production of inflammation-related mediators (NO, ROS, NF-κB, iNOS and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Perilla frutescents (L.) Britton var. frutescens was air-dried and extracted with ethanol. The extract dose-dependently decreased the generation of intracellular reactive oxygen species and dose-dependently increased antioxidant enzyme activities, such as superoxide dismutase, catalase and glutathione peroxidase in lipopolysaccharide stimulated RAW 264.7 macrophages. Also, Perilla frutescens (L.) Britton var. frutescens extract suppressed NO production in lipopolysaccharide-stimulated RAW 264.7 cells. The expressions of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), NF-κB, iNOS and COX-2 were inhibited by the treatment with the extract. Thus, this study shows the Perilla frutescens (L.) Britton var. frutescens extract could be useful for inhibition of the inflammatory process.
Related Links	http://dx.doi.org/10.3746/pnf.2012.17.2.109
Starting Page	109
File Format	PDF
ISSN	22878602
e-ISSN	22878602
Journal	Preventive Nutrition and Food Science
Issue Number	2
Volume Number	17
Language	English
Publisher	The Korean Society of Food Science and Nutrition
Publisher Date	2012-06-01
Access Restriction	Open
Rights Holder	The Korean Society of Food Science and Nutrition
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Food Science

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