NDLI: Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor

Content Provider	PubMed Central
Author	Grewal, Prabhjit K. Aziz, Peter V. Uchiyama, Satoshi Rubio, Gabriel R. Lardone, Ricardo D. Le, Dzung Varki, Nissi M. Nizet, Victor Marth, Jamey D.
Abstract	Sepsis occurs in the presence of a pathogen in the blood, often with increased blood clotting and inflammation that can cause severe tissue damage and organ failure leading to death. This article reports the mechanism of host protection mediated by the Ashwell-Morell receptor (AMR) of hepatocytes during sepsis caused by Streptococcus pneumoniae. The AMR protects the host primarily by diminishing the abundance of circulating platelets that have been remodeled by pathogen neuraminidase activity, thereby reducing the severity of coagulopathy, diminishing organ failure, and permitting host survival. The AMR is further selective in moderating circulating coagulation factors that are primarily prothrombotic. This study also presents an approach to preactivate AMR function early in sepsis to augment host protection and survival.
Related Links	http://dx.doi.org/10.1073/pnas.1313905110
Ending Page	20223
Page Count	6
Starting Page	20218
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	50
Volume Number	110
Language	English
Publisher	National Academy of Sciences
Publisher Date	2013-12-10
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor.

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling

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Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor.

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