NDLI: The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.

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Discrete wave mechanics: The hydrogen atom

From instability to irreversibility

Self-excited mono-ion oscillator

Persistent expression of v-mos oncogene in transformed cells that revert to nonmalignancy after prolonged treatment with interferon.

Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions.

Membrane lipid phase as catalyst for peptide-receptor interactions.

Rat cellular retinol-binding protein II: use of a cloned cDNA to define its primary structure, tissue-specific expression, and developmental regulation.

Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.

Immunocytochemical localization of component C of the methylreductase system in Methanococcus voltae and Methanobacterium thermoautotrophicum

Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid.

Substitution of a serine residue for proline-87 reduces catalytic activity and increases susceptibility to proteolysis of Escherichia coli adenylate kinase.

Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.

Regulation of fungal cell wall growth: a guanine nucleotide-binding, proteinaceous component required for activity of (1----3)-beta-D-glucan synthase.

Identification of the probable site of choleragen-catalyzed ADP-ribosylation in a Go alpha-like protein based on cDNA sequence.

Bacterial lipopolysaccharides, phorbol myristate acetate, and zymosan induce the myristoylation of specific macrophage proteins.

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse.

RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point.

Amino acid sequence of a prothoracicotropic hormone of the silkworm Bombyx mori

Adenovirus early region 1A protein increases the number of template molecules transcribed in cell-free extracts.

Inhibin A-subunit cDNAs from porcine ovary and human placenta.

Autogenous regulation of splicing of the transcript of a yeast ribosomal protein gene.

Hexose transport control in a fibroblast metabolic mutant can be promoted more effectively by D-allose than by glucose.

11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation.

Importance of the loop at residues 230-245 in the allosteric interactions of Escherichia coli aspartate carbamoyltransferase.

Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells.

Processing of phage T4 td-encoded RNA is analogous to the eukaryotic group I splicing pathway.

Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein.

Consecutive A X T pairs can adopt a left-handed DNA structure.

Affinity purification of sequence-specific DNA binding proteins.

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.

Affinity chromatography with an immobilized RNA enzyme.

Covalent modification of the glnG product, NRI, by the glnL product, NRII, regulates the transcription of the glnALG operon in Escherichia coli.

Identification of a factor in HeLa cells specific for an upstream transcriptional control sequence of an EIA-inducible adenovirus promoter and its relative abundance in infected and uninfected cells.

Ribonuclease H(70) from Saccharomyces cerevisiae possesses cryptic reverse transcriptase activity.

Functional domains of rabbit thrombomodulin.

Identification and characterization of the NMYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities.

Effect of amino acid substitutions on the catalytic and regulatory properties of aspartate transcarbamoylase.

A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.

Gene encoding the sigma 37 species of RNA polymerase sigma factor from Bacillus subtilis.

Spermine-DNA interactions: a theoretical study.

Replication forks are underrepresented in chromosomal DNA of Xenopus laevis embryos.

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Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

Receptor-mediated folate accumulation is regulated by the cellular folate content.

Leishmania and Trypanosoma surface glycoproteins have a common glycophospholipid membrane anchor.

Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells.

Analysis of sugar-binding sites in mammalian cell nuclei by quantitative flow microfluorometry.

Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells.

The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.

Isolation of point mutations in bacteriophage Mu attachment regions cloned in a lambda::mini-Mu phage.

Meiotic disjunction of circular minichromosomes in yeast does not require DNA homology.

Early postimplantation embryo lethality due to DNA rearrangements in a transgenic mouse strain.

Structure and expression of a tandem duplication of the Drosophila metallothionein gene.

Genes for the eight ribosomal proteins are clustered on the chloroplast genome of tobacco (Nicotiana tabacum): similarity to the S10 and spc operons of Escherichia coli.

Use of monosomics to map cloned DNA fragments in maize

Spermidine synthase of Escherichia coli: localization of the speE gene.

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

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Introduction of plasmid DNA into the trypanosomatid protozoan Crithidia fasciculata.

Evidence for haploidy in metacyclic forms of Trypanosoma brucei.

Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum.

Molecular analysis of the DNA sequences involved in the transcriptional regulation of the phosphate-repressible acid phosphatase gene (PHO5) of Saccharomyces cerevisiae.

Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes.

The specific direct interaction of helper T cells and antigen-presenting B cells.

Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb.

Clonal expansion of T cells: a cytotoxic T-cell response in vivo that involves precursor cell proliferation.

Plasmodium falciparum polypeptides associated with the infected erythrocyte plasma membrane.

Perturbation of the human T-cell antigen receptor-T3 complex leads to the production of inositol tetrakisphosphate: evidence for conversion from inositol trisphosphate.

Taste and salivary function.

Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones.

Human parathyroid antigen: characterization and localization with monoclonal antibodies.

Enhanced delivery to target cells by heat-sensitive immunoliposomes.

Comparison of constitutional and tumor-associated 11;22 translocations: nonidentical breakpoints on chromosomes 11 and 22.

Expression of type C-related endogenous retroviral sequences in human colon tumors and colon cancer cell lines.

Atrial natriuretic factor stimulates Na/K/Cl cotransport in vascular smooth muscle cells.

Co-clustering of denatured hemoglobin with band 3: its role in binding of autoantibodies against band 3 to abnormal and aged erythrocytes.

Chemical and functional correlates of postischemic renal ATP levels.

Characterization of major peptides in Creutzfeldt-Jakob disease and scrapie.

Patients with IgA nephropathy have circulating anti-basement membrane antibodies reacting with structures common to collagen I, II, and IV.

Biosynthesis and maturation of peroxisomal beta-oxidation enzymes in fibroblasts in relation to the Zellweger syndrome and infantile Refsum disease.

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Digital imaging of free calcium changes and of spatial gradients in growing processes in single, mammalian central nervous system cells.

Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream.

In situ hybridization to localize mRNA encoding the neurotransmitter synthetic enzyme glutamate decarboxylase in mouse cerebellum.

Hyperpolarization of the membrane potential caused by somatostatin in dissociated human pituitary adenoma cells that secrete growth hormone.

Dopaminergic control of 125I-labeled neurotensin binding site density in corticolimbic structures of the rat brain.

Tyrosine 3-hydroxylase in rat brain and adrenal medulla: hybridization histochemistry and immunohistochemistry combined with retrograde tracing.

Ethanol regulates calcium channels in clonal neural cells.

Control by cations of opioid binding in guinea pig brain membranes.

Cellular localization of proenkephalin mRNA in rat brain: gene expression in the caudate-putamen and cerebellar cortex.

Biphasic effects of estrogen on apolipoprotein synthesis in human hepatoma cells: Mechanism of antagonism by testosterone

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The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.

Content Provider	PubMed Central
Author	Due, C. Simonsen, M. Olsson, L.
Abstract	Monoclonal antibodies against some of the monomorphic determinants of major histocompatibility complex (MHC) class I molecules reduce insulin binding and precipitate 125I-labeled insulin receptor preparations. A monoclonal antibody with specificity for the insulin binding site on the cell membrane insulin receptor of human cells was used to precipitate insulin receptors from human cell lines and resulted in distinct bands of Mr approximately 130,000, 90,000, and 45,000. The Mr 45,000 molecules thus precipitated were subjected to NaDodSO4/PAGE, eluted from the gels, and found to react with monoclonal antibodies against monomorphic and a polymorphic MHC class I determinant known to be expressed on the cell line used as receptor source. Moreover, a murine thymoma line (RI) with MHC class I expression bound significant amounts of insulin, whereas a MHC class I-negative variant had low insulin binding capacity. Reduction in the density on human cells of the MHC class I heavy chain was obtained by capping with antibodies to beta 2-microglobulin or to the MHC class I heavy chain and resulted in decreased insulin binding, whereas down-regulation of insulin receptors induced increased density of MHC class I molecules. It is concluded that the MHC class I heavy chain and the tetrameric insulin receptor are structurally associated in the cell membrane and suggested that this association may occur by displacement of beta 2-microglobulin by the insulin receptor.
Starting Page	6007
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	83
Language	English
Publisher Date	1986-08-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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