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Shifting fitness landscapes in response to altered environments
| Content Provider | PubMed Central |
|---|---|
| Author | Hietpas, Ryan T. Bank, Claudia Jensen, Jeffrey D. Bolon, Daniel N. A. |
| Abstract | The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments. |
| Related Links | http://dx.doi.org/10.1111/evo.12207 |
| File Format | |
| ISSN | 00143820 |
| e-ISSN | 15585646 |
| Journal | Evolution; international journal of organic evolution |
| Issue Number | 12 |
| Volume Number | 67 |
| Language | English |
| Publisher Date | 2013-12-01 |
| Access Restriction | Open |
| Subject Keyword | Genetics Ecology, Evolution, Behavior and Systematics Agricultural and Biological Sciences(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Ecology, Evolution, Behavior and Systematics |
