NDLI: Progressive limb ataxia following inferior olive lesions

Content Provider	PubMed Central
Author	Horn, K. M. Deep, A. Gibson, A. R.
Copyright Year	2012
Abstract	Cerebellar climbing fibres originate in the inferior olive (IO). Temporary IO inactivation produces movement deficits. Does permanent inactivation produce similar deficits and, if so, do they recover? The excitotoxin, kainic acid, was injected into the rostral IO of three cats. Behaviour was measured during reaching and locomotion. Two cats were injected during the reaching task. Within minutes, grasping became difficult and the trajectories of the reaches showed higher arcing than normally seen. During locomotion, both cats showed head and trunk deviation to the injected side, walking paths curved to the injected side, and the paws were lifted higher than normal. Limbs contralateral to the injections became rigid. Within 1 day, posture had normalized, locomotion was unsteady and high lifting of the paws had reversed to a tendency to drag the dorsum of the paws. Passive body movement produced vestibular signs. Over a few days, locomotion normalized and vestibular signs disappeared. Reach trajectories were normal but grasping deficits persisted. Over the first week, the amplitude of limb lift during reaching and locomotion began to increase. The increase continued over time and, after several months, limb movements became severely ataxic. The effects followed the somatotopy of the rostral IO: a loss of cells in medial rostral IO only affected the forelimb, whereas a loss of cells in medial and lateral IO affected both forelimb and hindlimb. Deficits produced by IO lesions involve multiple mechanisms; some recover rapidly, some appear stable, and some worsen over time. The nature of the progressive deficit suggests a gradual loss of Purkinje cell inhibition on cerebellar nuclear cells.
Related Links	http://dx.doi.org/10.1113/jphysiol.2012.234898
Ending Page	5489
Page Count	15
Starting Page	5475
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 22
Volume Number	591
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2013-11-15
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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Progressive limb ataxia following inferior olive lesions

Dynamic characteristics of optokinetically controlled eye movements following inferior olive lesions in the brown rat.

Responses of single units in the inferior olive to stimulation of the limb nerves, peripheral skin receptors, cerebellum, caudate nucleus and motor cortex

Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive

Dynamic characteristics of optokinetically controlled eye movements following inferior olive lesions in the brown rat.

Responses in the inferior olive to stimulation of the cerebellar and cerebral cortices in the cat

Inferior olive inactivation decreases the excitability of the intracerebellar and lateral vestibular nuclei in the rat.

Responses in the dorsal accessory olive of the cat to stimulation of hind limb afferents

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Progressive limb ataxia following inferior olive lesions

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Progressive limb ataxia following inferior olive lesions

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