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Miniaturized Nuclear Magnetic Resonance Platform for Detection and Profiling of Circulating Tumor Cells
| Content Provider | PubMed Central |
|---|---|
| Author | Castro, Cesar M. Ghazani, Arezou A. Chung, Jaehoon Shao, Huilin David, Issadore Yoon, Tae-jong Weissleder, Ralph Lee, Hakho |
| Abstract | Accurate detection and profiling of circulating tumor cells (CTCs) is a highly sought after technology to improve cancer management. Such “liquid biopsies” could offer a non-invasive, repeatable window into each patient’s tumor, facilitating early cancer diagnosis and treatment monitoring. The rarity of CTCs, approximated at 1 CTC for every billion peripheral blood cells, however, poses significant challenges to sensitive and reliable detection. We have recently developed a new biosensor platform, namely a micro-nuclear magnetic resonance (µNMR). Through the synergistic integration of microfabrication, nanosensors, and novel chemistries, the µNMR platform offers high detection sensitivity and point-of-care operation, overcoming technical barriers in CTC research. We herein review the µNMR technology with emphasis on its application on CTC detection. Recent advances in the sensing technology will be summarized, followed by the description on the dynamic interplay between preclinical and clinical CTC studies. |
| Related Links | http://dx.doi.org/10.1039/c3lc50621e |
| File Format | |
| ISSN | 14730197 |
| e-ISSN | 14730189 |
| Journal | Lab on a chip |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry Bioengineering Chemistry(all) Biomedical Engineering Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering |
