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| Content Provider | PubMed Central |
|---|---|
| Author | Alfredo, Cruz-ramírez Sara, Díaz-triviño Wachsman, Guy Du, Yujuan Mario, Arteága-vázquez Zhang, Hongtao Benjamins, Rene Ikram, Blilou Neef, Anne B. Chandler, Vicki Ben, Scheres |
| Editor | Estelle, Mark |
| Copyright Year | 2013 |
| Abstract | Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage. |
| Related Links | http://dx.doi.org/10.1371/journal.pbio.1001724 |
| Starting Page | 1001724 |
| File Format | |
| ISSN | 15457885 |
| e-ISSN | 15457885 |
| Journal | PLoS Biology |
| Issue Number | 11 |
| Volume Number | 11 |
| Language | English |
| Publisher | Public Library of Science |
| Publisher Date | 2013-11-01 |
| Access Restriction | Open |
| Rights Holder | Public Library of Science |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Agricultural and Biological Sciences(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Microbiology Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences |
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