NDLI: Adenovirus E4orf4 Protein-Induced Death of p53−/− H1299 Human Cancer Cells Follows a G1 Arrest of both Tetraploid and Diploid Cells due to a Failure To Initiate DNA Synthesis

Content Provider	PubMed Central
Author	Cabon, Lauriane Sriskandarajah, Neera Mui, Melissa Z. Teodoro, Jose G. Blanchette, Paola Branton, Philip E.
Copyright Year	2013
Abstract	The adenovirus E4orf4 protein selectively kills human cancer cells independently of p53 and thus represents a potentially promising tool for the development of novel antitumor therapies. Previous studies suggested that E4orf4 induces an arrest or a delay in mitosis and that both this effect and subsequent cell death rely largely on an interaction with the B55 regulatory subunit of protein phosphatase 2A. In the present report, we show that the death of human H1299 lung carcinoma cells induced by expression of E4orf4 is typified not by an accumulation of cells arrested in mitosis but rather by the presence of both tetraploid and diploid cells that are arrested in G1 because they are unable to initiate DNA synthesis. We believe that these E4orf4-expressing cells eventually die by various processes, including those resulting from mitotic catastrophe.
Related Links	http://dx.doi.org/10.1128/jvi.01242-13
Ending Page	13178
Page Count	11
Starting Page	13168
File Format	PDF
ISSN	0022538X
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	24
Volume Number	87
Language	English
Publisher	American Society for Microbiology
Publisher Date	2013-12-15
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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