NDLI: Genome sequence of the human malaria parasite Plasmodium falciparum

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Genome sequence of the human malaria parasite Plasmodium falciparum

Content Provider	PubMed Central
Author	Gardner, Malcolm J. Hall, Neil Fung, Eula White, Owen Berriman, Matthew Hyman, Richard W. Carlton, Jane M. Pain, Arnab Nelson, Karen E. Bowman, Sharen Paulsen, Ian T. James, Keith Eisen, Jonathan A. Rutherford, Kim Salzberg, Steven L. Craig, Alister Kyes, Sue Chan, Man-suen Nene, Vishvanath Shallom, Shamira J. Suh, Bernard Peterson, Jeremy Sam, Angiuoli Pertea, Mihaela Allen, Jonathan Selengut, Jeremy Haft, Daniel Mather, Michael W. Vaidya, Akhil B. Martin, David M. A. Fairlamb, Alan H. Fraunholz, Martin J. Roos, David S. Ralph, Stuart A. Mcfadden, Geoffrey I. Cummings, Leda M. Subramanian, G. Mani Mungall, Chris Venter, J. Craig Carucci, Daniel J. Hoffman, Stephen L. Newbold, Chris Davis, Ronald W. Fraser, Claire M. Barrell, Bart
Copyright Year	2002
Abstract	The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host–parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.
Related Links	http://dx.doi.org/10.1038/nature01097
File Format	PDF
ISSN	00280836
e-ISSN	14764687
Journal	Nature
Issue Number	6906
Volume Number	419
Language	English
Publisher Date	2002-10-03
Access Restriction	Open
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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