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Cardiac Peroxisome Proliferator-Activated Receptor-γ Expression is Modulated by Oxidative Stress in Acutely Infrasound-Exposed Cardiomyocytes
| Content Provider | PubMed Central |
|---|---|
| Author | Pei, Zhaohui Meng, Rongsen Zhuang, Zhiqiang Zhao, Yiqiao Liu, Fangpeng Zhu, Miao-zhang Li, Ruiman |
| Abstract | The aim of the present study was to examine the effects of acute infrasound exposure on oxidative damage and investigate the underlying mechanisms in rat cardiomyocytes. Neonatal rat cardiomyocytes were cultured and exposed to infrasound for several days. In the study, the expression of CAT, GPx, SOD1, and SOD2 and their activities in rat cardiomyocytes in infrasound exposure groups were significantly decreased compared to those in the various time controls, along with significantly higher levels of O2 − and H2O2. Decreased cardiac cell viability was not observed in various time controls. A significant reduction in cardiac cell viability was observed in the infrasound group compared to the control, while significantly increased cardiac cell viability was observed in the infrasound exposure and rosiglitazone pretreatment group. Compared to the control, rosiglitazone significantly upregulated CAT, GPx, SOD1, and SOD2 expression and their activities in rat cardiomyocytes exposed to infrasound, while the levels of O2 − or H2O2 were significantly decreased. A potential link between a significant downregulation of PPAR-γ expression in rat cardiomyocytes in the infrasound group was compared to the control and infrasound-induced oxidative stress. These findings indicate that infrasound can induce oxidative damage in rat cardiomyocytes by inactivating PPAR-γ. |
| Related Links | http://dx.doi.org/10.1007/s12012-013-9211-5 |
| Ending Page | 315 |
| Page Count | 9 |
| Starting Page | 307 |
| File Format | |
| ISSN | 15307905 |
| e-ISSN | 15590259 |
| Journal | Cardiovascular Toxicology |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-12-01 |
| Access Restriction | Open |
| Rights Holder | Springer US |
| Subject Keyword | Toxicology Molecular Biology Cardiology and Cardiovascular Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Toxicology Cardiology and Cardiovascular Medicine |
