NDLI: Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy

Content Provider	PubMed Central
Author	Zhang, Rongxiao Gladstone, David J. Jarvis, Lesley A. Strawbridge, Rendall R. Hoopes, P. Jack Friedman, Oscar D. Glaser, Adam K. Pogue, Brian W.
Abstract	Cherenkov radiation is induced when charged particles travel through dielectric media (such as biological tissue) faster than the speed of light through that medium. Detection of this radiation or excited luminescence during megavoltage external beam radiotherapy (EBRT) can allow emergence of a new approach to superficial dose estimation, functional imaging, and quality assurance for radiation therapy dosimetry. In this letter, the first in vivo Cherenkov images of a real-time Cherenkoscopy during EBRT are presented. The imaging system consisted of a time-gated intensified charge coupled device (ICCD) coupled with a commercial lens. The ICCD was synchronized to the linear accelerator to detect Cherenkov photons only during the 3.25-μs radiation bursts. Images of a tissue phantom under irradiation show that the intensity of Cherenkov emission is directly proportional to radiation dose, and images can be acquired at 4.7 frames / s with SNR > 30 . Cherenkoscopy was obtained from the superficial regions of a canine oral tumor during planned, Institutional Animal Care and Use Committee approved, conventional (therapeutically appropriate) EBRT irradiation. Coregistration between photography and Cherenkoscopy validated that Cherenkov photons were detected from the planned treatment region. Real-time images correctly monitored the beam field changes corresponding to the planned dynamic wedge movement, with accurate extent of overall beam field, and expected cold and hot regions.
Related Links	http://dx.doi.org/10.1117/1.jbo.18.11.110504
Starting Page	110504
File Format	PDF
ISSN	10833668
e-ISSN	15602281
Journal	Journal of Biomedical Optics
Issue Number	11
Volume Number	18
Language	English
Publisher	Society of Photo-Optical Instrumentation Engineers
Publisher Date	2013-11-18
Access Restriction	Open
Rights Holder	Society of Photo-Optical Instrumentation Engineers
Subject Keyword	Atomic and Molecular Physics, and Optics Electronic, Optical and Magnetic Materials Biomaterials Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Biomaterials Electronic, Optical and Magnetic Materials Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation

Clinical confocal microlaparoscope for real-time in vivo optical biopsies

Real-time snapshot hyperspectral imaging endoscope

Real-time absorption reduced surface fluorescence imaging

Imaging a photodynamic therapy photosensitizer in vivo with a time-gated fluorescence tomography system

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo

Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography

Motion-gated acquisition for in vivo optical imaging

Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy

Similar Documents

Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation

Clinical confocal microlaparoscope for real-time in vivo optical biopsies

Real-time snapshot hyperspectral imaging endoscope

Real-time absorption reduced surface fluorescence imaging

Imaging a photodynamic therapy photosensitizer in vivo with a time-gated fluorescence tomography system

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo

Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography

Motion-gated acquisition for in vivo optical imaging

Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy