NDLI: Pharmaceutical drugs supporting regeneration of small-intestinal mucosa severely damaged by ionizing radiation in mice

Content Provider	PubMed Central
Author	Ishihara, Hiroshi Tanaka, Izumi Yakumaru, Haruko Tanaka, Mika Yokochi, Kazuko Akashi, Makoto
Copyright Year	2013
Abstract	Accidental exposure of the abdomen to high-dose radiation leads to severe consequences initiated by disruption of the mucosa in the small intestine. Therapeutic options are limited, even though various treatments have been investigated, particularly in the field of regenerative therapy. In order to identify readily available treatment methods, we included several current pharmaceutical drugs, for which the clinical trials have already been completed, in tests on mice that had undergone severe mucosal damage by radiation. The drugs were injected into mice 24 h after exposure to 15.7 Gy X-rays. The effects of the drugs on the damaged mucosa of the small intestine were evaluated using early regeneration indices [the expression of c-myb mRNA, and proliferation of epithelial cells in the form of microcolonies (MCs) by Days 4 and 5 post-irradiation] and the survival rate of the mice. Enhancement of mucosal regeneration at Day 4 (c-myb: P < 0.01, MC: P < 0.05) and improvement of the survival rate (P < 0.05) were observed when a clinical dose of gonadotropin, a stimulator of androgen, was injected. Similarly, a clinical dose of thiamazole (which prevents secretion of thyroid hormone) stimulated mucosal growth by Day 5 (c-myb: P < 0.01, MC: P < 0.05) and also improved the survival rate (P < 0.05). The nonclinical drugs histamine and high-dose octreotide (a growth hormone antagonist) also gave significant survival-enhancing benefits (P < 0.01 and P < 0.05, respectively). These results can be used to construct therapeutic programs and applied in various experimental studies to control the regeneration of damaged mucosa.
Related Links	http://dx.doi.org/10.1093/jrr/rrt077
Ending Page	1064
Page Count	8
Starting Page	1057
File Format	PDF
ISSN	04493060
e-ISSN	13499157
Journal	Journal of Radiation Research
Issue Number	6
Volume Number	54
Language	English
Publisher	Oxford University Press
Publisher Date	2013-11-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Health, Toxicology and Mutagenesis Radiation Radiology Nuclear Medicine and imaging Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Health, Toxicology and Mutagenesis Radiation

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