NDLI: Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells

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Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells

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Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells

Content Provider	PubMed Central
Author	Youn, Cha Kyung Park, Seon Joo Lee, Min Young Cha, Man Jin Kim, Ok Hyeun You, Ho Jin Chang, In Youp Yoon, Sang Pil Jeon, Young Jin
Copyright Year	2013
Abstract	We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells. Western blot analysis showed silibinin inhibits iNOS gene expression. RT-PCR showed that silibinin inhibits iNOS, TNF-α, and IL1β. We also showed that silibinin strongly inhibits p38 MAPK phosphorylation, whereas the ERK1/2 and JNK pathways are not inhibited. The p38 MAPK inhibitor abrogated the LPS-induced nitrite production, whereas the MEK-1 inhibitor did not affect the nitrite production. A molecular modeling study proposed a binding pose for silibinin targeting the ATP binding site of p38 MAPK (1OUK). Collectively, this series of experiments indicates that silibinin inhibits macrophage activation by blocking p38 MAPK signaling.
Related Links	http://dx.doi.org/10.4062/biomolther.2013.044
Starting Page	258
File Format	PDF
ISSN	20054483
e-ISSN	20054483
Journal	Biomolecules & Therapeutics
Issue Number	4
Volume Number	21
Language	English
Publisher	The Korean Society of Applied Pharmacology
Publisher Date	2013-07-30
Access Restriction	Open
Rights Holder	The Korean Society of Applied Pharmacology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Biochemistry Molecular Medicine Pharmacology

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Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells.

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