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Simple Synthesis of Amides and Weinreb Amides via Use of PPh3 or Polymer-Supported PPh3 and Iodine
| Content Provider | PubMed Central |
|---|---|
| Author | Kumar, Amit Akula, Hari Kiran Lakshman, Mahesh K. |
| Copyright Year | 2009 |
| Abstract | The combination of PPh3/I2 has been shown to be effective for conversion of a range of carboxylic acids to 2°, 3°, and Weinreb amides. Simplification of the procedure was possible with the use of polymer-supported PPh3/I2. Weinreb amides produced via the use of polymer-supported PPh3 could be filtered through a short silica gel plug and used in further transformations. Thus, use of polymer-supported PPh3 offers potential applicability to diversity-oriented reactions. Formal total syntheses of apocynin and pratosine, as well as syntheses of anhydrolychorinone and hippadine, have been achieved via the use of this amide-forming method. An attempt has been made to gain insight into this reaction. |
| Related Links | http://dx.doi.org/10.1002/ejoc.200901420 |
| File Format | |
| ISSN | 1434193X |
| Journal | European journal of organic chemistry |
| Issue Number | 14 |
| Volume Number | 2010 |
| Language | English |
| Publisher Date | 2010-05-01 |
| Access Restriction | Open |
| Subject Keyword | Physical and Theoretical Chemistry Organic Chemistry Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Physical and Theoretical Chemistry |
