NDLI: Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence

Content Provider	PubMed Central
Author	Huang, Tianxiang Jin, Xin He, Lei Zhang, Mingyu Wu, Jun Wang, Yanjin Fang, Jiasheng
Copyright Year	2013
Abstract	The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration of chemotherapeutic agents. The immunohistochemical analysis of 102 patient samples revealed that a high expression of PODX was significantly associated with high-grade astrocytomas (P<0.001) and a high Ki-67 labeling index (LI; P<0.001). A Kaplan-Meier survival analysis demonstrated that the high PODX expression group had significantly shorter disease-free survival (DFS) and overall survival (OS) rates compared with the low expression group (P<0.001). The multivariate analysis using the Cox’s proportional hazards model revealed that a high expression of PODX, a high World Health Organization grade and a high Ki-67 LI were independent factors for shorter DFS and OS times. A subsequent in vitro study using SW1783 and U-87 human astrocytoma cell lines revealed that knocking down PODX decreased astrocytoma cell viability against temozolomide-induced apoptotic stress through the inhibition of the Akt survival signaling pathway. In conclusion, the in vivo findings indicated that a high expression of PODX is predictive of a poor survival outcome and, thus, may be used as a prognostic factor to predict the survival outcomes of astrocytoma patients. The in vitro findings indicated that PODX may promote astrocytoma cell viability against chemotherapeutic agent-induced apoptotic stress through the Akt pathway, indicating that PODX may be a novel target for overcoming chemoresistance in astrocytomas.
Related Links	http://dx.doi.org/10.3892/ol.2013.1556
Starting Page	1390
File Format	PDF
ISSN	17921074
e-ISSN	17921082
Journal	Oncology Letters
Issue Number	5
Volume Number	6
Language	English
Publisher	D.A. Spandidos
Publisher Date	2013-09-01
Access Restriction	Open
Rights Holder	D.A. Spandidos
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide

Involvement of Platelet–Tumor Cell Interaction in Immune Evasion. Potential Role of Podocalyxin-Like Protein 1

Effects of dexamethasone and betamethasone on in vitro cultures from human astrocytoma.

In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance

Podocalyxin is a marker of poor prognosis in colorectal cancer

Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer

Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

The doppel (Dpl) Protein Influences In Vitro Migration Capability in Astrocytoma-Derived Cells

Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence

Similar Documents

Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide

Involvement of Platelet–Tumor Cell Interaction in Immune Evasion. Potential Role of Podocalyxin-Like Protein 1

Effects of dexamethasone and betamethasone on in vitro cultures from human astrocytoma.

In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance

Podocalyxin is a marker of poor prognosis in colorectal cancer

Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer

Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

The doppel (Dpl) Protein Influences In Vitro Migration Capability in Astrocytoma-Derived Cells

Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence