NDLI: Global DNA methylation remodeling accompanies CD8 T cell effector function 1

Content Provider	PubMed Central
Author	Scharer, Christopher D. Barwick, Benjamin G. Youngblood, Benjamin A. Ahmed, Rafi Boss, Jeremy M.
Abstract	The differentiation of CD8 T cells in response to acute infection results in the acquisition of hallmark phenotypic effector functions, however the epigenetic mechanisms that program this differentiation process on a genome-wide scale are largely unknown. Here we report the DNA methylomes of antigen-specific naïve and day 8 effector CD8 T cells following acute LCMV infection. During effector CD8 T cell differentiation, DNA methylation was remodeled such that changes in DNA methylation at gene promoter regions negatively correlated with gene expression. Importantly, differentially methylated regions (DMRs 2 ) were enriched at cis-elements, including enhancers active in naïve T cells. DMRs were associated with cell type-specific transcription factor binding sites, and these transcription factors clustered into modules that define networks targeted by epigenetic regulation and control of effector CD8 T cell function. Changes in the DNA methylation profile following CD8 T cell activation, revealed numerous cellular processes, cis-elements, and transcription factor networks targeted by DNA methylation. Together, the results demonstrated that DNA methylation remodeling accompanies the acquisition of the CD8 T cell effector phenotype and repression of the naïve cell state. These data therefore provide the framework for an epigenetic mechanism that is required for effector CD8 T cell differentiation and adaptive immune responses.
Related Links	http://dx.doi.org/10.4049/jimmunol.1301395
Ending Page	3429
Page Count	11
Starting Page	3419
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	6
Volume Number	191
Language	English
Publisher Date	2013-09-15
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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