NDLI: A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24

Content Provider	PubMed Central
Author	Hakonarson, Hakon Bjornsdottir, Unnur S. Eva, Halapi Palsson, Snaebjorn Adalsteinsdottir, Elva Gislason, David Finnbogason, Gudmundur Gislason, Thorarinn Kristjansson, Kristleifur Arnason, Thor Birkisson, Illugi Frigge, Michael L. Kong, Augustine Gulcher, Jeffrey R. Stefansson, Kari
Copyright Year	2002
Abstract	Asthma is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Numerous loci and candidate genes have been reported to show linkage and association to asthma and atopy. Although some studies reporting these observations are compelling, no gene has been mapped that confers a sufficiently high risk of asthma to meet the stringent criteria for genomewide significance. Using 175 extended Icelandic families that included 596 patients with asthma, we performed a genomewide scan with 976 microsatellite markers. The families were identified by cross-matching a list of patients with asthma from the Department of Allergy/Pulmonary Medicine of the National University Hospital of Iceland with a genealogy database of the entire Icelandic nation. We detected linkage of asthma to chromosome 14q24, with an allele-sharing LOD score of 2.66. After we increased the marker density within the locus to an average of one microsatellite every 0.2 cM, the LOD score rose to 4.00. We designate this locus “asthma locus one” (AS1). Taken together, these results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24.
Related Links	http://dx.doi.org/10.1086/342205
Ending Page	491
Page Count	9
Starting Page	483
File Format	PDF
ISSN	00029297
e-ISSN	15376605
Journal	American Journal of Human Genetics
Issue Number	3
Volume Number	71
Language	English
Publisher	The American Society of Human Genetics
Publisher Date	2002-09-01
Access Restriction	Open
Rights Holder	The American Society of Human Genetics
Subject Keyword	Genetics(clinical) Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A major susceptibility gene for asthma maps to chromosome 14q24.

A Major Susceptibility Locus for Systemic Lupus Erythemathosus Maps to Chromosome 1q31

A Major Lung Cancer Susceptibility Locus Maps to Chromosome 6q23–25

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.

A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p

A New Susceptibility Locus for Autosomal Dominant Pancreatic Cancer Maps to Chromosome 4q32-34

A Major Locus for Myoclonus-Dystonia Maps to Chromosome 7q in Eight Families

A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24

Similar Documents

A major susceptibility gene for asthma maps to chromosome 14q24.

A Major Susceptibility Locus for Systemic Lupus Erythemathosus Maps to Chromosome 1q31

A Major Lung Cancer Susceptibility Locus Maps to Chromosome 6q23–25

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.

A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p

A New Susceptibility Locus for Autosomal Dominant Pancreatic Cancer Maps to Chromosome 4q32-34

A Major Locus for Myoclonus-Dystonia Maps to Chromosome 7q in Eight Families

A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24