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| Content Provider | PubMed Central |
|---|---|
| Author | Bjork, Jason W. Johnson, Sandra L. Tranquillo, Robert T. |
| Copyright Year | 2010 |
| Abstract | Most cross-linking methods utilize chemistry or physical processes that are detrimental to cells and tissue development. Those that are not as harmful often do not provide a level of strength that ultimately meets the required application. The purpose of this work was to investigate the use of a ruthenium-sodium persulfate cross-linking system to form dityrosine in fibrin-based engineered tissue. By utilizing the tyrosine residues inherent to fibrin and cell-deposited proteins, at least 3-fold mechanical strength increases and 10-fold stiffness increases were achieved after cross-linking. This strengthening and stiffening effect was found to increase with culture duration prior to cross-linking such that physiologically relevant properties were obtained. Fibrin was not required for this effect as demonstrated by testing with collagen-based engineered tissue. Cross-linked tissues were implanted subcutaneously and shown to have minimal inflammation after 30 days, similar to non-cross-linked controls. Overall, the method employed is rapid, non-toxic, minimally inflammatory, and is capable of increasing strength and stiffness of engineered tissues to physiological levels. |
| Related Links | http://dx.doi.org/10.1016/j.biomaterials.2010.12.010 |
| Starting Page | 2479 |
| File Format | |
| ISSN | 18785905 |
| e-ISSN | 18785905 |
| Journal | Biomaterials |
| Issue Number | 10 |
| Volume Number | 32 |
| Language | English |
| Publisher Date | 2011-04-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Nanoscience and Nanotechnology Mechanics of Materials Biomaterials Biophysics Bioengineering |
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